Many kratom consumers use kratom for the analgesic properties the plant produces. The leaves of the plant were used as a traditional folk medicine to remedy pain for centuries. For the longest time, the only evidence we had to support its pain-relieving capabilities were the anecdotal reports of kratom users. But luckily for the kratom industry, that’s slowly changing. Each year, the scientific community releases additional studies on the kratom plant. And that research supports things said about kratom for a few hundred years. And recently, the latest released research indicated that kratom showed promise for treating opioid dependency, too.
The Food and Drug Administration (FDA) has repeatedly claimed that kratom is a dangerously addictive substance. However, when we read through scientific data, we discover that scientists claim kratom users are not at risk of abusing kratom because the addictive properties are almost nonexistent.
The FDA has been questioned about these findings, too. Yet, it never provided a coherent response on the issue. Instead, the agency always reverts to old data that it took out of context.
Regardless, the scientific community continues to investigate the truth about kratom. The researchers have one goal in mind: to provide valuable data that results from the scientific method.
And recently, another team of researchers released the findings of their work to the world. According to the findings, the alkaloids found in kratom showed less physical dependence on test subjects than typical opioids. Also, the results suggested kratom improved the conditions of opioid withdrawal.
The researchers heard the anecdotal reports from kratom users that the plant helped alleviate opioid withdrawal without increasing sensitivity to pain. So the team of scientists wanted to test the claim and see if it had any merit. To conduct the test, the researchers used three different kratom-associated products in the experiment. The first substance was a combined kratom alkaloid extract (KAE). (This extract had every alkaloid in kratom present in the finished product.) The scientists also used the isolated mitragynine compound. And finally, they utilized the analog mitragynine pseudoindoxyl (MP). (Mitragynine pseudoindoxyl is a semi-synthetic analog of mitragynine: it’s more potent in comparison.)
For five days, the scientists gave the different test groups of mice repeated doses of the dedicated substances. The control group received saline. One group received morphine. Another group got KAE. A test group was administered mitragynine. And the last group received MP. By the end of the five-day period, the mice treated chronically with morphine, KAE, or mitragynine demonstrated significant drug-induced hyperalgesia. Then the researchers administered naloxone to the test subjects. (Naloxone is a medication that reverses an opioid overdose by acting as an opioid antagonist in a patient.) The naloxone immediately sent them into withdrawal.
The researchers tested for withdrawal signs in the mice. The results showed that the kratom alkaloid extract, mitragynine, and mitragynine pseudoindoxyl demonstrated significantly fewer naloxone-precipitated withdrawal signs than morphine-treated mice. Those results proved that morphine is more addictive than the kratom compounds. But the scientists continued to push forward.
The researchers also wanted to determine the therapeutic potential for using kratom to treat morphine addiction. Tons of anecdotal reports indicate that opioid addicts have used kratom to get sober. And the researchers wanted to test those claims. So they also conducted a separate experiment to see how morphine-addicted mice would fare using kratom as a treatment.
The scientists once again got a group of mice addicted to morphine. However, this time, instead of giving them naloxone, the researchers gave the addicted mice the different kratom formulas for the next three days. But one group of mice, the control group, continued to receive morphine until the conclusion of the experiment.
But for the other test groups, one of the physically dependent groups of mice received the combined kratom alkaloid extract for three days. The group received a dose twice daily.
Another group of addicted mice was administered mitragynine twice a day for the following three days.
The last group of test subjects that were addicted to morphine was given mitragynine pseudoindoxyl for a total of three days. Likewise, the mice got their doses two times a day.
After the third day, the scientists then administered naloxone to the test groups. The mice went into a forced withdrawal. However, the mice that had received the different kratom-derived products demonstrated significantly fewer signs of precipitated withdrawal compared to the control group.
And those results suggest that kratom does have the potential for treating opioid addiction. So we should push for further studies.
As the experiment came to its closure, the researchers put their findings together. The scientists concluded that the combined kratom alkaloid extract, mitragynine, and mitragynine pseudoindoxyl produced significantly less physical dependence than morphine. The results also showed that giving morphine-dependent mice kratom for a few days before forcing them to undergo precipitated withdrawal provided a better outcome on their condition. And that suggests that kratom has the potential to be used for opioid treatment.
The first discovery of the experiment is important because Americans are in the middle of an opioid epidemic. And the national issue has only grown in 2020—thanks to the conditions implemented during the pandemic. So, instead of the government attacking the kratom plant, they should be allowing larger grants to get presented to scientists for research purposes. The money we throw away on a failing “War on Drugs” would be more beneficial to spend on remedying the addiction problem that millions of Americans continue to face.
The second findings indicate that we could potentially use kratom to treat opioid addicts in our nations. Until kratom makes it to clinical trials, the government should back away from attacking the plant. It’s too beneficial for America. The natural plant product may help to end our public health crisis. Besides, kratom is a much healthier alternative than the dangerous synthetic opioids that doctors currently prescribe to treat addicts. Plus, kratom is inexpensive. Right now, lots of people are hurting financially. Trying to get sober shouldn’t break the bank.
Now, the scientific results from several recent studies have provided humanity with recurring conclusions. And that’s great. The more research we receive that leads to the same outcome, the better. That means future studies may move from scientific research over to clinical trials. Should that happen—and the results are favorable, then the FDA can no longer argue that kratom does not have medicinal properties. If they were, it would put them at odds with the medical community. However, it wouldn’t be the first time. The FDA has yet to admit that cannabis has medical potential, either.
But clinical trials are a long way off. We need to focus on the here and now. And state legislators need to be educated on these discoveries as well. So you can use the scientific data provided when presenting an argument before state representatives. Inform your congressmen that—regardless of what the FDA claims—kratom consumers cannot overdose on kratom.
In the meantime, our fight to protect the sanctity of scientific exploration over the molecules in kratom continues. And Kratom Geek will make sure to give you front-seat access to those discoveries as they get presented to the world.
An educated populace is a force to be reckoned with. And that’s something our government fears. But rest assured, we’ll make sure to equip you with the knowledge that the FDA doesn’t want you to possess. After all, it will take our combined forces to stop the government from infringing on our freedom.